This report demonstrates that MMDF is more effective than a single MDF to uncover phase  I and II metabolites from hydrolysis or N-dealkylation, even when the products from such processes have mass defects that are significantly different from the parent. MMDF allows users to use low threshold values during data processing so that metabolites at very low levels can be easily identified.

The resulting chromatogram from MMDF is accurate and specific because it is based on exact mass and mass deficiencies, which are highly specific to the parent druc compound. It provides speed, sensitivity and accuracy to facilitate the identification of drug metaboites in drug discovery and development. 

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