| Type 2 diabetes is the most common metabolic disease. Although the
prevention and control of it remains unclear, there is strong evidence that
dietary factors play a role in the onset of this disease. Previous studies have
indicated that cinnamon may mimic insulin effects and thus may improve glucose
uptake. Considering the complex composition of cinnamon, it is important to be
able to isolate and characterize the possible active components in it. A range
of reports have been devoted to the studies of this topic. However, most work
has been mainly focused on the studies of monomer and dimers. The study of
trimer or even larger compounds using on-line LC/MSn approach has not been reported.
The fast cycle time and excellent MSn sensitivity of the LCQ Fleet ion trap mass spectrometer provide enhanced analytical throughput for complex natural product analysis. In this report, profiling and structural elucidation of polyphenol polymers, the possible active compounds in cinnamon, are carried out using an LC/MSn methodology using the LCQ Fleet ion trap mass spectrometer.
The application of pulsed-Q dissociation (PQD™) and high resolution isolation (HRI) facilitates the analysis of this complex sample.
To read/download the complete application note, please use the
link at the left of this page. |
0 Items 