ADME/Tox profiling has become increasingly important for efficient drug candidate selection and optimization of a compound's physicochemical properties. Point solutions such as standalone spreadsheet and graphing tools are inefficient, prone to errors and lead to inconsistent results. Template modifications propagated over time cause variations in data handling and problematic 'apples to apples' comparisons. The lack of a central repository results in data being maintained in disparate locations without traceability. A fully functional database system can reduce effort and manpower required and increase throughput by automating complex experiment templating, instrument interfacing, data analysis as well as review and acceptance tasks.

Thermo Scientific Galileo LIMS provides simple, easy-to-use data processing, graphing, data review and reporting while also facilitating consolidation and automation of multiple processes. Furthermore, flexible calculation settings enable laboratories to follow their standard procedures. Experimental set-up is fast and easy requiring no programming. Moreover, the system is capable of performing automatic re-calculation after outlier data is removal. User-definable calculations using Microsoft Excel spreadsheets are controlled and stored securely in Galileo LIMS database, adding security and allowing GLP compliance if necessary. Users are allowed to set up their own tree-style logic for flagging of results.

The study design of Thermo Scientific Galileo LIMS templates allows specification of key experimental variables including drug and inhibitor concentrations, species, biomatrix, tissue, analytical time points, assay methods and result calculation options. Manual data transfer to external software for processing and storage is virtually eliminated. Instrument data can be rapidly imported via Rapid Study Entry using a simple dialog to populate the template with analytical results and hence automatic calculation of ADME/Tox parameters.

The system's Gallery presents data in tabular, thumbnail or detailed views. The thumbnail view allows users to scan quickly across many datasets while the details view allows users to 'drill-down' into a data set. Results are automatically calculated when the charting galleries are opened and re-calculated whenever outlier points are deactivated. ADME/Tox parameters can be flagged automatically in the Gallery or in the Details view using green, yellow or red flags to indicate acceptable, questionable or rejected results for each drug candidate.  

The new poster was originally presented at the LabAutomation 2007 conference.

For more information about Thermo Scientific Galileo LIMS or to obtain a free-of-charge copy of the technical poster, please call +781-287-4865 or for the UK office call +44 -161-942-3074, e-mail marketing.informatics@thermofisher.com or visit www.thermo.com/informatics.

About Thermo Fisher Scientific
Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, enabling our customers to make the world healthier, cleaner and safer. With annual sales of more than $9 billion, we employ 30,000 people and serve over 350,000 customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions, government agencies as well as environmental and industrial process control settings. Serving customers through two premier brands, Thermo Scientific and Fisher Scientific, we help solve analytical challenges from routine testing to complex research and discovery. Thermo Scientific offers customers a complete range of high-end analytical instruments as well as laboratory equipment, software, services, consumables and reagents to enable integrated laboratory workflow solutions. Fisher Scientific provides a complete portfolio of laboratory equipment, chemicals, supplies and services used in healthcare, scientific research, safety and education. Together, we offer the most convenient purchasing options to customers and continuously advance our technologies to accelerate the pace of scientific discovery, enhance value for customers and fuel growth for shareholders and employees alike. Visit www.thermofisher.com.