| One of the most critical issues in near-infrared (NIR) spectroscopy, historically, has been Method Transfer. Method Transfer can be defined as the ability to take a calibration developed on one instrument and use it to analyze samples on another instrument with the same accuracy and precision without adjusting the model. Commonly, NIR methods are developed by a chemist in an analytical laboratory using both laboratory and process samples. When the method is completed, validated and ready for use, it is migrated to the area closer to the process in order to achieve the substantial Return-on-Investment (ROI) that online NIR analysis offers. But what happens if the online instrument is substantially different than the instrument where the calibration was developed ? Poor, inconsistent instrument design can lead to method bias, poor prediction capacity or substantially increased calibration error requiring significant time commitments to remedy. In this case, each instrument becomes its own, distinct calibration challenge quickly chipping away at the cost savings derived from using online NIR. The Antaris™ line of NIR process analyzers makes Method Transfer a reality by incorporating robust engineering with a high-quality optical design. Diamond-turned mirrors and pinned-in-place optics combined with the outstanding stability of the flex-pivot interferometer provide the easiest method transfer available. Across the entire family of Antaris process analyzers, methods transfer seamlessly so you don’t have to spend your time adjusting each single instrument deployed for a dedicated purpose. | Design of ExperimentInstrument: Antaris Method Development System
Technique: Heated Liquid Transmission
Rationale: The above experiment negates two major sources of variability in sampling, pathlength and temperature. The transmission cell gives a consistent pathlength across measurements. The heating action of the cell holder ensures both the sample and cell are kept at one temperature minimizing any spectral effects from temperature gradients.
Samples: Quantified, binary mixtures of Hexane and Heptane (Photometric Grade) is an almost ideal chemical system for these measurements due to the lack of almost any intermolecular interactions that might be encountered with aqueous or –OH containing systems. The temperature, in this case, should be kept at approximately 35°C as these solvents have a vapor pressure at STP. |
0 Items 
