microRNAs are key regulators of gene expression and are implicated in pathogenesis. To better understand microRNA function, we provide miRIDIAN microRNA Mimics and Inhibitors for efficient and specific modulation of miRNA activity.
miRIDIAN miRNA Mimics
• Effective mimic of endogenous mature miRNA • Supplement miRNA activity to study gain-of-function effects • Programming of RISC with active mature miRNA and exclusion of passenger strand for specific effects
• Effective inhibition of endogenous mature miRNA function by means of innovative design • Superior potency compared to conventional 21-23mer 2’-O-methyl-modified RNA oligonucleotides designed antisense to the mature miRNA • Highly potent and persistent inhibition at low concentrations
• Non-targeting mimics and inhibitors for use as controls in miRNA experiments • Allow distinction between mimic or inhibitor activity and background effects
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