| The major value of FT-NIR spectroscopy compared to other analytical techniques is rapid, accurate, multi-component analysis online in real-time. The greatest time and cost savings come when implementing NIR analysis in the plant. Whether it is in a chemical plant to monitor catalyst concentration or in the polymer plant to look at reaction kinetics or in the pharmaceutical industry to look at real time blend homogeneity, the Antaris™ line of NIR analyzers has a proven track record of robust, precise analysis in rugged environments allowing operators or control systems the flexibility to make real-time decisions that will maximize yield and increase the bottom line. One of the most important decisions that is made when going online with NIR analysis is the choice of probe type and fiber. Although choosing a rugged, robust analyzer is critical to success in process analysis, selecting the right probe type for the application at hand is equally as important. Probes come in many different shapes and sizes, all specifically tailored to your application. A collection of dedicated probes is listed below. - Polymer extrusion head for transmission and reflection
- Retractable, self-cleaning diffuse reflection probe for fluid bed dryers
- Double O-ring seal probe for sterility in biological manufacturing.
- Non-contact diffuse reflection probes for moving samples like medicated webs or roll paper
- Self-purging probe for powder-based applications
- SabIR probe with handle and trigger for Raw Material ID.
Process communications also plays a pivotal role in online process analysis. Once the analytical data has been acquired, it needs to be put to use. But how? RESULT™ software allows the user to automatically communicate to process equipment using Analog or Digital I/O as well as using an internal OPC server communicating via ethernet. Antaris NIR analyzers grow your bottom line by helping you understand the way your processes work. NIR analyzers can look into your process and determine if you are blending powders too long, or cooking reactants too little. This critical in-process information can be used effectively to mitigate risk and drive cost-savings. | Design of ExperimentInstrument: Antaris EX C1Z2-rated FT-NIR analyzer with self-cleaning, retractable diffuse reflection probe.
Technique: Online Fluid Bed Dryer Analysis
Rationale: Fluid bed dryers take a good deal of man- and electrical-power to run. With online FT-NIR data doing real-time drying analysis and controling for moisture or other solvents, the dryer can be used more efficiently and the plant can save costs by only doing as much drying as needed.
Samples: Grab samples were collected to build a calibration over two trial runs in the pilot plant. The dryer was charged and ramped up. At five-minute intervals, samples were taken from the sampling port while an FT-NIR spectrum was taken. The samples were sealed tightly in pre-dried glass vials and taken to the QC lab for moisture analysis. The calibration set consisted of 40 calibration standards run on the same material throughout the entire drying cycle in order to represent the true sample variability. |
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